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Rani Therapeutics to Present Preclinical Data on Oral Delivery of Semaglutide via the RaniPill® Capsule at ObesityWeek® 2025

MWN-AI** Summary

Rani Therapeutics Holdings, Inc., a clinical-stage biotherapeutics company, is set to present exciting preclinical data regarding its RaniPill® capsule technology at ObesityWeek® 2025, which will take place in Atlanta, Georgia, from November 4-7, 2025. The presentation aims to showcase the efficacy of oral semaglutide (RT-116) in a study involving dogs, highlighting that its bioavailability matches that of subcutaneous injections while also delivering comparable weight loss results.

Scheduled for November 6, 2025, during a dedicated poster session, the research will be presented by Dr. Kyle Horlen, Vice President of Nonclinical Development at Rani Therapeutics. The poster, numbered 647, will be located in Exhibit Hall A1 at the Georgia World Congress Center. This session is expected to draw significant attention from researchers, clinicians, and investors interested in breakthroughs in obesity treatment and drug delivery innovations.

Rani Therapeutics specializes in developing novel oral delivery systems aimed at simplifying the administration of biologics and drugs, which traditionally require injections. The RaniPill® capsule is a proprietary technology designed to enable patients to take medications orally, enhancing convenience and compliance. Previous studies have demonstrated the safety, tolerability, and bioavailability of the RaniPill® capsule, marking a significant advancement in drug delivery systems.

As Rani Therapeutics prepares for its presentation, it aims to position itself as a key player in the biopharmaceutical industry, potentially revolutionizing treatment options for obesity and other conditions requiring injectable therapies. With increasing interest in non-invasive drug delivery methods, Rani's developments could reshape the landscape of how therapies are administered and consumed, driving future growth and innovation within the sector.

MWN-AI** Analysis

Rani Therapeutics Holdings, Inc. (Nasdaq: RANI) continues to make strides in the biotherapeutics space, especially regarding the oral delivery of biologics, as evidenced by its upcoming presentation at ObesityWeek® 2025. The company will present preclinical data demonstrating that its RaniPill® capsule, designed to deliver Semaglutide orally, is bioequivalent to traditional subcutaneous injections, while also eliciting similar weight loss results. This data could be pivotal for Rani, as it aims to replace cumbersome injection methods with a more patient-friendly oral delivery system.

Investors should closely monitor the outcomes of this presentation on November 6, 2025, as positive results could potentially catalyze significant momentum in Rani's stock price. The obesity treatment market remains highly lucrative, and successful demonstration of effective oral delivery could position Rani as a formidable player amid a competitive landscape.

The announcement holds particular weight as obesity continues to be a major public health concern, driving demand for innovative therapies. If Rani's technology indeed mirrors the efficacy of established treatments like Semaglutide injections, it may promote quicker adoption by both patients and healthcare providers, ultimately leading to increased market share.

However, potential investors should be mindful of certain risks. The biotechnology sector often experiences volatility, particularly around clinical data releases. Additionally, regulatory hurdles could delay commercialization efforts. It is crucial to assess Rani’s cash runway and funding strategy, as significant investment is required to advance into clinical trials and potentially bring oral Semaglutide to market.

In conclusion, while the data from ObesityWeek could serve as a catalyst for Rani Therapeutics, careful analysis of the company’s clinical progress and market positioning will be essential for any investment decisions moving forward.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

SAN JOSE, Calif., Oct. 30, 2025 (GLOBE NEWSWIRE) -- Rani Therapeutics Holdings, Inc. (“Rani Therapeutics” or “Rani”) (Nasdaq: RANI), a clinical-stage biotherapeutics company focused on the oral delivery of biologics and drugs, today announced that it will present preclinical data on the RaniPill® capsule, the company’s oral delivery platform, at ObesityWeek® 2025 taking place both virtually and in-person on November 4-7, 2025 in Atlanta, Georgia.

Details of the presentation are as follows:

Abstract Title: Oral Semaglutide (RT-116) in Dogs is Bioequivalent to SC Injections and Elicits Similar Weight Loss
Session Type: Poster Session
Poster Number: 647
Location: Georgia World Congress Center, Exhibit Hall A1
Session Date & Time: November 6, 2025 from 2:30 pm – 3:30 pm E.T.
Presenting Author: Kyle Horlen, DVM, VP of Nonclinical Development

About Rani Therapeutics

Rani Therapeutics is a clinical-stage biotherapeutics company focused on advancing technologies to enable the development of orally administered biologics and drugs. Rani has developed the RaniPill® capsule, which is a novel, proprietary and patented platform technology, intended to replace subcutaneous injection or intravenous infusion of biologics and drugs with oral dosing. Rani has successfully conducted several preclinical and clinical studies to evaluate safety, tolerability and bioavailability using RaniPill® capsule technology.

Investor Contact:

investors@ranitherapeutics.com

Media Contact:

media@ranitherapeutics.com


FAQ**

How does the bioequivalence of oral Semaglutide (RT-116) in dogs impact the potential market for Rani Therapeutics Holdings Inc. RANI's oral delivery platform for future weight loss treatments?

The bioequivalence of oral Semaglutide (RT-116) in dogs enhances Rani Therapeutics Holdings Inc.'s credibility and potential market position for its oral delivery platform, indicating promising efficacy and safety for future weight loss treatments in humans.

What specific safety and tolerability measures has Rani Therapeutics Holdings Inc. RANI assessed in their preclinical studies with the RaniPill® capsule?

Rani Therapeutics Holdings Inc. has assessed specific safety and tolerability measures for the RaniPill® capsule in preclinical studies by evaluating gastrointestinal irritation, systemic exposure, immune response, and potential toxicological effects to ensure its clinical viability.

What are the future clinical development plans for Rani Therapeutics Holdings Inc. RANI following the findings presented at ObesityWeek® 2025 regarding the RaniPill® capsule?

Following the findings presented at ObesityWeek® 2025, Rani Therapeutics Holdings Inc. plans to advance the clinical development of the RaniPill® capsule for obesity treatment, focusing on expanding its efficacy studies and seeking regulatory approvals for commercialization.

How does Rani Therapeutics Holdings Inc. RANI plan to leverage the results from their presentations at events like ObesityWeek® to engage with investors and potential partners?

Rani Therapeutics Holdings Inc. plans to leverage results from events like ObesityWeek® to showcase the efficacy of their innovative delivery system, thereby attracting investors and potential partners through demonstrated advancements in obesity treatment and strategic collaboration opportunities.

**MWN-AI FAQ is based on asking OpenAI questions about Rani Therapeutics Holdings Inc. (NASDAQ: RANI).

Rani Therapeutics Holdings Inc.

NASDAQ: RANI

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