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TScan Therapeutics to Host Virtual KOL Event to Discuss Clinical Updates from the ALLOHA(TM) Phase 1 Trial and Future Market Opportunities

MWN-AI** Summary

TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biotechnology firm, has announced an upcoming virtual key opinion leader (KOL) event set for December 8, 2025, at 8:00 a.m. ET. The event will focus on clinical updates from the ALLOHA™ Phase 1 trial, which evaluates TSC-101, a T cell receptor (TCR)-engineered T cell (TCR-T) therapy designed to treat patients with hematologic malignancies following allogeneic hematopoietic cell transplantation (HCT). Data from this trial will be highlighted at the 67th American Society of Hematology (ASH) Annual Meeting.

Attendees can expect a comprehensive review of two-year relapse data from initial patients in the ongoing ALLOHA trial. The company plans to share insights into its enhanced commercial manufacturing process, implemented in the ALLOHA trial and slated for use in an upcoming pivotal trial scheduled for the second quarter of 2026. Additionally, TScan will outline the unmet medical needs in the oncology space and discuss the market potential for TSC-101 and its follow-on product candidates.

Notable speakers at the event include Dr. Ran Reshef from Columbia University Irving Medical Center, TScan’s CEO Gavin MacBeath, and Stephen Camiolo, Senior Vice President of Market Access at TScan Therapeutics. The company invites interested parties to register for the live event, with a replay expected to be available on their website post-event.

TScan is dedicated to innovating TCR-T therapies not only for hematologic cancers but also for solid tumors through its TargetScan platform, which aims to identify new therapeutic targets in T cell-mediated autoimmune disorders.

MWN-AI** Analysis

TScan Therapeutics, Inc. (Nasdaq: TCRX) is poised to capture attention in the biotechnology arena with its upcoming virtual KOL event focused on updates from the ALLOHA™ Phase 1 trial. This event, scheduled for December 8, 2025, will unveil critical two-year relapse data on TSC-101, a T cell receptor (TCR)-engineered therapy designed for hematologic malignancies. Stakeholders should consider the implications of this event for both the company and the broader market landscape.

The ALLOHA trial is pivotal as it investigates TSC-101's efficacy in patients undergoing allogeneic hematopoietic cell transplantation (HCT), a crucial therapeutic context given the high risk of relapse in these patients. The presentation of long-term data from this trial could significantly influence investor sentiment and market perception, particularly if positive outcomes are reported.

Moreover, TScan's introduction of an improved commercial-ready manufacturing process enhances the scalability of their TCR-T therapies, positioning the company favorably for the upcoming pivotal trials slated for 2026. This development addresses key bottlenecks often associated with cell therapy production, indicating that TScan is not only advancing its clinical endeavors but also enhancing its operational readiness for commercialization.

Market opportunities for TScan are robust, particularly within the realms of unmet medical needs in hematologic cancers. Should TSC-101 demonstrate significant efficacy, the potential for market penetration is substantial. As such, investors may find value in closely monitoring the outcomes of the KOL event and subsequent data releases, which could provide a clearer picture of TScan's trajectory.

Given these dynamics, a cautious optimistic stance is warranted. Investors should consider initiating positions ahead of the event but remain vigilant about market reactions to the unveiled data and any subsequent strategic partnerships that may arise.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

WALTHAM, Mass., Dec. 03, 2025 (GLOBE NEWSWIRE) -- TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biotechnology company focused on the development of T cell receptor (TCR)-engineered T cell (TCR-T) therapies for the treatment of patients with cancer, today announced the Company will host a virtual key opinion leader (KOL) event to discuss updated data from the ALLOHA™ Phase 1 trial being presented at the 67 th American Society of Hematology (ASH) Annual Meeting and Exposition and the future market opportunity for its heme program. The virtual event will take place on Monday, December 8, at 8:00 a.m. ET.

The event will provide an in-depth review of the poster presented at the ASH Annual Meeting, including two-year relapse data on initial patients from TScan’s ongoing ALLOHA Phase 1 trial evaluating TSC-101 in patients with heme malignancies undergoing allogeneic hematopoietic cell transplantation (HCT). The Company will discuss its improved commercial-ready manufacturing process that has recently been implemented in the ALLOHA Phase 1 trial and will be used in the upcoming pivotal trial scheduled to start in the second quarter of 2026. The Company will also review the unmet medical need and potential market opportunity for TSC-101 and follow-on product candidates.

Featured speakers include:

  • Ran Reshef, M.D., M.Sc., Director of Translational Research, Blood and Marrow Transplantation Program, Director of the Cell Therapy Program, Columbia University Irving Medical Center
  • Gavin MacBeath, Ph.D., Chief Executive Officer, TScan Therapeutics
  • Stephen Camiolo, Senior Vice President, Market Access, TScan Therapeutics

Registration for the live event can be found here . A replay will be made available on the “ Events and Presentations ” section of the Company’s website at ir.tscan.com .

About TScan Therapeutics, Inc.

TScan is a clinical-stage biotechnology company focused on the development of T cell receptor (TCR)-engineered T cell (TCR-T) therapies for the treatment of patients with cancer. The Company’s lead TCR-T therapy candidate is in development for the treatment of patients with hematologic malignancies to prevent relapse following allogeneic hematopoietic cell transplantation (the ALLOHA Phase 1 heme trial). The Company has developed multiple TCR-T therapy candidates for solid tumors and is currently developing methods for in vivo engineering using these candidates. The Company is also applying their TargetScan platform to discover novel targets in various T cell-mediated autoimmune disorders.

Contacts

Troy Neubecker
TScan Therapeutics, Inc.
Investor Relations
857-399-9517
tneubecker@tscan.com

Melissa Forst
Argot Partners
212-600-1902
TScan@argotpartners.com


FAQ**

What are the key insights that TScan Therapeutics Inc. TCRX expects to share during the KOL event regarding the two-year relapse data from the ALLOHA Phase 1 trial?

TScan Therapeutics Inc. TCRX anticipates discussing the significant efficacy and safety findings from the two-year relapse data of the ALLOHA Phase 1 trial, highlighting key patient outcomes and the potential for their T-cell receptor platform in treating cancer.

How does TScan Therapeutics Inc. TCRX plan to leverage its improved commercial-ready manufacturing process for the upcoming pivotal trial starting in Q2 2026?

TScan Therapeutics Inc. (TCRX) plans to leverage its improved commercial-ready manufacturing process for the upcoming pivotal trial starting in Q2 2026 by enhancing the scalability, consistency, and efficiency of its cell therapy products to optimize clinical outcomes and accelerate regulatory approvals.

Can TScan Therapeutics Inc. TCRX elaborate on the unmet medical needs and potential market opportunity they foresee for TSC-101 in the context of hematologic malignancies?

TScan Therapeutics Inc. believes TSC-101 addresses significant unmet medical needs in treating hematologic malignancies by targeting tumor-specific T cell receptors, potentially improving efficacy and outcomes for patients with resistant or relapsed cancers in a growing market.

What potential follow-on product candidates will TScan Therapeutics Inc. TCRX discuss that could expand their TCR-T therapy offerings for both hematologic and solid tumors?

TScan Therapeutics Inc. is expected to discuss follow-on product candidates targeting additional tumor-associated antigens and enhanced TCR-T therapies that could broaden their offerings for both hematologic malignancies and solid tumors.

**MWN-AI FAQ is based on asking OpenAI questions about TScan Therapeutics Inc. (NASDAQ: TCRX).

TScan Therapeutics Inc.

NASDAQ: TCRX

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