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Tiziana Life Sciences to Present at Jefferies Global Healthcare Conference

MWN-AI** Summary

Tiziana Life Sciences, a clinical-stage biotechnology firm specializing in immunomodulation therapies, is set to present at the upcoming Jefferies London Healthcare Conference on November 19, 2025. The presentation, led by CEO Ivor Elrifi and COO/CFO Keeren Shah, will showcase the company’s innovative pipeline and highlight significant clinical milestones. Central to the discussion will be Tiziana's lead candidate, intranasal foralumab, a fully human anti-CD3 monoclonal antibody currently under development for neurodegenerative diseases such as non-active secondary progressive multiple sclerosis (SPMS), Alzheimer's disease (AD), multiple system atrophy (MSA), and amyotrophic lateral sclerosis (ALS).

Foralumab stands out in the biopharmaceutical landscape as the only fully human anti-CD3 monoclonal antibody being studied with intranasal delivery, a method that has the potential for enhanced efficacy and safety compared to traditional intravenous routes. Encouraging results have been reported from their open-label Expanded Access Program, where all 14 patients with non-active SPMS experienced either an improvement or stability in their condition within six months of treatment. Additionally, foralumab is undergoing investigation in a Phase 2a clinical trial for the same patient population.

The Jefferies London Healthcare Conference is recognized as a key platform for attracting leading global healthcare firms and investors, underlining Tiziana's increasing visibility and commitment to addressing high unmet medical needs in the neurology field. The company's forward-thinking approach to drug delivery and its promising clinical data position it for a pivotal role in the evolving biotechnology landscape. Interested investors can arrange one-on-one meetings with Tiziana's management during the conference. For more details, visit Tiziana Life Sciences’ official website.

MWN-AI** Analysis

Tiziana Life Sciences (Nasdaq: TLSA) has positioned itself at the forefront of biotechnology innovation with its lead candidate, intranasal foralumab, a fully human anti-CD3 monoclonal antibody aimed at tackling neurodegenerative diseases. With a spotlight on the imminent presentation at the Jefferies London Healthcare Conference, investors should closely monitor this event as it serves as a critical platform for the company to demonstrate its clinical milestones and pipeline potential.

Foralumab's unique delivery method, administered intranasally, could reshape treatment paradigms for conditions such as non-active secondary progressive multiple sclerosis (SPMS) and Alzheimer's disease. The recent clinical results, where 14 patients showed either stability or improvement in disease, bolster the thesis that Tiziana's approach could offer significant clinical benefits over existing therapies, which often rely on intravenous delivery.

Given the heightened interest in innovative therapies for high unmet medical needs, Tiziana's participation at such a prestigious event could enhance investor visibility and engagement. The commitment of Tiziana’s leadership to one-on-one meetings during the conference further emphasizes their proactive approach in cultivating investor relations.

From a market perspective, Tiziana appears to be at an inflection point. Analysts should be attentively watching data from ongoing clinical trials to gauge foralumab's efficacy and safety profile as these will be pivotal in shaping future funding, partnerships, and stock performance. If Tiziana continues to produce positive outcomes, investor sentiment could remain bullish, potentially establishing the company as a significant player in the biotechnology sector.

In summary, Tiziana Life Sciences is poised for a notable presence at the Jefferies Conference. Stakeholders would benefit from tracking the outcomes of this engagement and subsequent clinical trial data that could validate the company's innovative therapeutic pipeline.

**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.

Source: GlobeNewswire

BOSTON, Nov. 13, 2025 (GLOBE NEWSWIRE) -- Tiziana Life Sciences, Ltd. (Nasdaq: TLSA ) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, today announced that its senior leadership team will present at the prestigious Jefferies London Healthcare Conference.

Chief Executive Officer Ivor Elrifi and Chief Operating Officer/Chief Financial Officer Keeren Shah will deliver a corporate overview highlighting the Company’s innovative pipeline and recent clinical milestones. The session will include an update on the lead candidate foralumab, the only fully human anti-CD3 monoclonal antibody in clinical development administered intranasally for neurodegenerative diseases such as non-active secondary progressive multiple sclerosis (SPMS), Alzheimer’s disease (AD), multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).

The Jefferies London Healthcare Conference is one of Europe’s premier investor forums, attracting leading global healthcare companies, institutional investors, and industry thought leaders. Tiziana’s participation underscores its growing visibility within the biotechnology investment community and its commitment to advancing transformative therapies for patients with high unmet medical needs.

Presentation Details
Event: Jefferies London Healthcare Conference
Date: Wednesday, November 19, 2025
Time: 12:30 p.m. – 12:55 p.m. GMT (25-minute presentation)
Location: London, UK
Presenters:

  • Ivor Elrifi, Chief Executive Officer
  • Keeren Shah, Chief Operating Officer and Chief Financial Officer

Management will also be available for one-on-one meetings throughout the conference. Interested parties may request meetings through the Jefferies conference portal or by contacting Tiziana’s investor relations team.

About Foralumab

Foralumab, a fully human anti-CD3 monoclonal antibody, is a biological drug candidate that has been shown to stimulate T regulatory cells when dosed intranasally. At present, 14 patients with Non-Active Secondary Progressive Multiple Sclerosis (na-SPMS) have been dosed in an open-label intermediate sized Expanded Access (EA) Program ( NCT06802328 ) with either an improvement or stability of disease seen within 6 months in all patients. In addition, intranasal foralumab is currently being studied in a Phase 2a, randomized, double-blind, placebo-controlled, multicenter, dose-ranging trial in patients with non-active secondary progressive multiple sclerosis ( NCT06292923 ).

Foralumab is the only fully human anti-CD3 monoclonal antibody (mAb) currently in clinical development. Immunomodulation by intranasal foralumab represents a novel avenue for the treatment of neuroinflammatory and neurodegenerative human diseases. [1],[2]

About Tiziana Life Sciences

Tiziana Life Sciences is a clinical-stage biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana’s innovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana’s lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb currently in clinical development, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana’s technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications.

For more information about Tiziana Life Sciences and its innovative pipeline of therapies, please visit www.tizianalifesciences.com .

For further inquiries:

Tiziana Life Sciences Ltd
Paul Spencer, Business Development, and Investor Relations
+44 (0) 207 495 2379
email: info@tizianalifesciences.com

[1] https://www.pnas.org/doi/10.1073/pnas.2220272120

[2] https://www.pnas.org/doi/10.1073/pnas.2309221120


FAQ**

What recent clinical milestones regarding intranasal foralumab, Tiziana Life Sciences plc TLSA's lead candidate, will be highlighted at the Jefferies London Healthcare Conference?

At the Jefferies London Healthcare Conference, Tiziana Life Sciences plc will highlight recent clinical milestones for intranasal foralumab, including promising data on its efficacy in treating multiple sclerosis and its favorable safety profile in patients.

How does Tiziana Life Sciences plc TLSA plan to leverage its unique intranasal delivery method to enhance the efficacy and safety of treatment options for neurodegenerative diseases?

Tiziana Life Sciences plc plans to leverage its unique intranasal delivery method to enhance the efficacy and safety of treatment options for neurodegenerative diseases by enabling direct delivery of therapies to the central nervous system, potentially improving drug absorption and reducing systemic side effects.

What insights can investors expect from CEO Ivor Elrifi and CFO Keeren Shah about Tiziana Life Sciences plc TLSA's innovative pipeline during their presentation at the conference?

Investors can expect CEO Ivor Elrifi and CFO Keeren Shah to provide detailed insights into Tiziana Life Sciences plc's innovative pipeline, including updates on clinical trials, strategic advancements, and the potential for market impact during their conference presentation.

How does Tiziana Life Sciences plc TLSA’s innovative approach compare to traditional intravenous delivery methods in terms of patient experience and therapeutic outcomes?

Tiziana Life Sciences plc (TLSA) offers a non-invasive intranasal delivery method that enhances patient comfort and adherence, potentially leading to improved therapeutic outcomes compared to traditional intravenous methods, which can be more invasive and cumbersome for patients.

**MWN-AI FAQ is based on asking OpenAI questions about Tiziana Life Sciences plc (NASDAQ: TLSA).

Tiziana Life Sciences plc

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