IRAK4 oral degrader KT-474 (SAR444656) expected to complete enrollment in both Phase 2 HS and AD studies in fourth quarter of 2024, with topline data expected in first half of 2025
STAT6 oral degrader KT-621, with dupilumab-like activity, expected to enter Phase 1 clinical trial in the second half of 2024
TYK2 oral degrader KT-294, with a TYK2 loss-of-function profile and expected biologics-like activity, planned to enter Phase 1 clinical trial in the first half of 2025
STAT3 degrader KT-333 and MDM2 degrader KT-253 expected to complete Phase 1a studies in 2024 and deliver additional proof-of-concept data defining path to late-stage development
Well-capitalized, with cash in excess of $745 million1 and expected runway into the first half of 2027, enabling expansion into areas with large clinical and commercial opportunities
Kymera to present company update and 2024 outlook at J.P. Morgan Annual Healthcare Conference on Tuesday, January 9, 2024, at 9:00 a.m. PT/12:00 p.m. ET
WATERTOWN, Mass., Jan. 09, 2024 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ:KYMR), a clinical-stage biopharmaceutical company advancing a new class of small molecule medicines using targeted protein degradation (TPD), today announced its corporate goals for 2024, including anticipated progress on its best-in-class pipeline of immunology and oncology programs.
"Kymera has taken important steps toward our goal of building a fully integrated, global biotechnology company, demonstrating our ability to consistently deliver first- and best-in-class programs that target validated pathways with the potential to address large, underserved disease areas and create significant value for patients and shareholders," said Nello Mainolfi, Ph.D., Founder, President and CEO, Kymera Therapeutics. "We're building an industry-leading oral immunology portfolio, beginning with our IRAK4 degrader, KT-474, which we expect to complete enrollment in two Phase 2 studies later this year, and continuing with our recently announced oral STAT6 and TYK2 degrader programs, which have the potential to revolutionize how we treat many immuno-inflammatory diseases using oral medicines with biologics-like efficacy. In addition, we are advancing our two novel oncology programs targeting STAT3 and MDM2, both of which we expect to deliver additional proof-of-concept data and comprehensive Phase 1 data in 2024, giving us multiple clinical catalysts in the year ahead."
Dr. Mainolfi continued, "Importantly, we have in excess of $745 million of cash1, providing expected runway now into the first half of 2027. This will enable us to deliver the next stage of the company's growth and is expected to take the company past our Phase 2 data for KT-474, our oncology proof-of concept readouts, and several clinical inflection points for our two recently-announced immunology programs, STAT6 and TYK2."
Kymera's corporate goals for 2024 include:
Immunology Portfolio
Kymera is working to build an industry-leading oral immunology pipeline by leveraging its disease agnostic discovery platform, deep expertise gained through the development of its first-in-class IRAK4 program, and unique target selection strategy that focuses on genetically and clinically validated pathways, to build a portfolio of oral medicines with efficacy comparable to in-pathway biologics.
- Collaborate with Sanofi to complete enrollment of the KT-474/SAR444656 (IRAK4) Phase 2 hidradenitis suppurativa and atopic dermatitis clinical trials, with topline data expected to be reported in the first half of 2025
KT-474 (SAR444656) is an oral IRAK4 degrader, in development for the treatment of IL-1R/TLR-driven complex inflammatory diseases. Sanofi, which is collaborating with Kymera on the development of KT-474 outside of the oncology and immune-oncology fields, is conducting the Phase 2 studies. Kymera has an option after Phase 2 and prior ...