When we refer to valuation multiples, Price/Earnings and EV/EBITDA are some of the most commonly referred to.
One of the largest differences between these multiples comes from EV (Enterprise Value), taking into account debt, while Price/Earnings doesn't. That much is known. A typical formula for EV will be "EV = Market capitalization + net debt + minorities at market - extra operating assets". Within these, market capitalization (price x diluted shares outstanding) and net debt will generally be the most important components.
What's less talked about regarding the two valuation multiples (P/E and EV/EBITDA) is