Inflammation is a physiological part of the complex biological response of tissues to counteract various harmful signals. Inflammation involves diverse factors such as immune cells, blood vessels, and nerves as sources of mediators. Among these factors, serine proteases are key elements in both physiological and pathological inflammation.Kallikrein-7 (KLK7) belongs to a large KLK family of serine proteases, which is involved in extracellular matrix remodeling, skin desquamation (shedding), hormone precursor processing and regulation of tumor cell proliferation by activating growth factor and hydrolyzing growth factor binding proteins. It has been reported that several KLK members were dysregulated in cancer cells and correlated with tumor progression. KLKs are also involved in many key aspects of epidermal biology, including desquamation, permeability barrier formation, inflammation, and host defense. KLK5, KLK7, and KLK14 are major proteases involved in skin desquamation.KLK7 is primarily expressed in keratinocytes, and once it has been synthesized, it is exported to the outer skin layers. KLK7 biology is particularly well understood in the context of its role in skin homeostasis. Abnormal expression of KLKs may destroy the skin barrier homeostasis, causing a range of skin diseases such as Netherton syndrome (NS), atopic dermatitis (AD), rosacea, and psoriasis. KLK7 inhibitors such as SPINK5 play an important role in maintaining a balance between skin shedding and the development of new skin cells, thereby maintaining healthy skin tissues. Read More >>