2024-07-09 14:50:00 ET
Summary
- Paxlovid treatment consists, each dose, of three pills: two of nirmatrelvir and one of ritonavir.
- Ibuzatrelvir fits right into the active site of the coronavirus main protease.
- So as long as we have the current coronvirus with us - and it looks to be settling in for a good long while - this looks like it'll be a front-line therapy once it completes testing and is approved by the FDA.
Here's a look at the next iteration of Pfizer's ([[PFE]], [[PFE:CA]]) now-well-known antiviral, Paxlovid. As those who have taken it know, the treatment consists, each dose, of three pills: two of nirmatrelvir (the antiviral itself) and one of ritonavir ( updated to fix those numbers, since I'd clearly blocked out the experience of taking it! ). And even though that has a generic name that tells you of its antiviral origins, ritonavir has no antiviral activity towards coronaviruses at all. It's there as a very effective inhibitor of CYP3A4, one of the most common drug-metabolizing enzymes in the liver, which would otherwise tear down the nirmatrelvir to therapeutically useless levels....
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For further details see:
The Next Paxlovid