Ascendis Pharma Reports Fourth Quarter and Full-Year 2025 Financial Results
MWN-AI** Summary
Ascendis Pharma A/S reported its fourth-quarter and full-year financial results for 2025, showcasing significant growth and progress in its product pipeline. For Q4 2025, the company achieved product revenues of €240 million, contributing to a total of €684 million for the full year, compared to €364 million in 2024. The company's operating profit for the last quarter was €10 million, with operating cash flow reaching €73 million, highlighting effective management despite ongoing investments in R&D.
Jan Mikkelsen, CEO, emphasized the company’s commitment to innovation, aiming for €500 million in operating cash flow and at least €5 billion in global annual product revenue by 2030, facilitated by its TransCon technology platform. Key revenue streams included YORVIPATH, which brought in €187 million in Q4 and €477 million for the year, and SKYTROFA, which generated €53 million in Q4.
Looking ahead, Ascendis is advancing its drug development initiatives, notably the TransCon CNP for pediatric achondroplasia, currently under FDA Priority Review, with a PDUFA action goal date set for February 28, 2026. The company is also engaging in label expansions for its existing therapies and is keen on developing new combination treatments.
Total revenues for FY 2025 amounted to €720 million, benefiting from the robust demand for YORVIPATH while navigating a decrease in non-product revenues. Ascendis reported an overall net loss of €228 million for the year, aggrandized by increased operating expenses primarily due to global expansion efforts.
The company maintains a solid cash position with €616 million on hand and intends to initiate a $120 million share repurchase program in 2026. A conference call to discuss these results further is scheduled for later today.
MWN-AI** Analysis
Ascendis Pharma's recent fourth quarter and full-year 2025 financial results showcase significant growth, with Q4 product revenue of €240 million and full-year revenue of €684 million, primarily driven by the strong performance of YORVIPATH. The company's strategic focus on developing its TransCon technology platform appears to be yielding promising results, as reflected in their robust cash flow from operating activities of €73 million for Q4.
One of the standout metrics is the anticipated FDA Priority Review of TransCon CNP, with a PDUFA action date set for February 28, 2026. This could potentially unlock substantial market value for Ascendis, as it targets a pediatric demographic with high unmet medical needs in achondroplasia. The completion of various ongoing trials, including the reACHin trial and label expansion efforts for TransCon CNP, underscores Ascendis's commitment to enhancing its product portfolio.
Investors should closely monitor Ascendis's operational progress as it aims to generate approximately €500 million in cash flow in 2026 while aiming for a target of at least €5 billion in annual revenue by 2030. The company is also initiating a $120 million share repurchase program, signaling confidence in its long-term vision and providing investor return strategies.
As the competitive landscape intensifies, Ascendis’s ability to leverage its innovative pipeline and expand its market presence will be crucial. The growth of YORVIPATH, particularly with a reported €477 million in annual sales, indicates that patient and healthcare provider adoption is on an upward trajectory. Furthermore, Ascendis must manage its increasing SG&A costs, which nearly doubled in 2025, to ensure sustainable profitability.
Overall, Ascendis Pharma presents a compelling investment opportunity for growth-oriented investors, particularly with significant catalysts on the horizon. The upcoming conference call could provide additional insights into their strategies and operational outlook, making it a crucial event for stakeholders.
**MWN-AI Summary and Analysis is based on asking OpenAI to summarize and analyze this news release.
- Q4 2025 product revenue of €240 million and FY 2025 product revenue of €684 million
- Q4 2025 operating profit of €10 million and cash flow from operating activities of €73 million
- TransCon® CNP under FDA Priority Review, PDUFA action goal date of February 28, 2026
- Conference call today at 4:30 pm ET
COPENHAGEN, Denmark, Feb. 11, 2026 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq: ASND) today announced financial results for the fourth quarter and full year ended December 31, 2025, and provided a business update.
“With a continued focus on making a meaningful difference for patients, we believe Ascendis is entering a steep growth phase as we transform into a leading global biopharma company,” said Jan Mikkelsen, President and CEO of Ascendis Pharma. “With strong execution and the power of our TransCon platform, we are positioned to generate approximately €500 million in operating cash flow in 2026 while aspiring to deliver at least €5 billion in global annual product revenue by 2030. At the same time, we are advancing a growing pipeline of highly differentiated programs to deliver durable, long-term growth.”
Select 2025 Highlights & Anticipated 2026 Milestones
- TransCon PTH
(palopegteriparatide, marketed as YORVIPATH)- YORVIPATH revenue for the fourth quarter of 2025 totaled €187 million and €477 million for the full year 2025, as previously announced.
- More than 5,300 unique U.S. patient enrollments, with nearly 2,400 unique prescribing healthcare providers at year end.
- Outside the U.S., now available commercially or through named patient programs in more than 30 countries, with full commercial launches anticipated in 10 additional countries by year end 2026.
- Presented pooled analysis of 3-year data from PaTHway and PaTH Forward trials at the American Society of Nephrology (ASN) Kidney Week 2025, reinforcing that treatment with TransCon PTH led to rapid and sustained improvements in kidney function in adults with hypoparathyroidism.
- Ongoing label expansion trials through PaTHway60 (adults) and PaTHway Adolescent.
- Confirmed product profile for once-weekly TransCon PTH, targeting patients who have been transitioned from conventional therapy to YORVIPATH and have achieved a stable daily dose.
- TransCon CNP
(navepegritide, FDA NDA and EMA MAA filed)- In the U.S., PDUFA action goal date of February 28, 2026 for pediatric achondroplasia.
- Submitted marketing authorization application (MAA) to the European Medicines Agency (EMA) in October 2025, with a regulatory decision on potential use in pediatric achondroplasia anticipated in the fourth quarter of 2026.
- Label expansion trial in infants with achondroplasia, reACHin, remains ongoing with enrollment completion anticipated later this year.
- TransCon CNP + TransCon hGH Combination Therapy
(navepegritide plus lonapegsomatropin)- Announced Week 52 topline results from Phase 2 COACH Trial, which demonstrated improvements in annualized growth velocity across both TransCon CNP treatment-naïve and TransCon CNP-treated children that exceeded the 97th percentile of average stature children, along with improvements in body proportionality and in arm span, and a safety profile consistent with those observed for monotherapies of TransCon CNP and TransCon hGH on January 8, 2026.
- Held a successful end of Phase 2 meeting with the U.S. Food & Drug Administration (FDA) and Scientific Advice meeting in the EU regarding a Phase 3 trial of TransCon CNP and TransCon hGH in pediatric achondroplasia in the fourth quarter of 2025.
- Week 78 COACH data update anticipated in second quarter of 2026.
- Planned new trials to support TransCon CNP + TransCon hGH treatment in additional indications.
- TransCon hGH
(lonapegsomatropin, marketed as SKYTROFA)- SKYTROFA revenue for the fourth quarter of 2025 totaled €53 million and €206 million for the full year 2025, as previously announced.
- Received first label expansion in July 2025 with FDA approval for adult growth hormone deficiency (GHD).
- Initiated Phase 3 basket trial for additional indications: idiopathic short stature (ISS), SHOX deficiency, Turner syndrome, and small for gestational age (SGA).
- Oncology Program
(onvapegleukin alfa)
-
- Expect to report median overall survival (OS) data for a cohort of 70 patients with late-line platinum-resistant ovarian cancer (PROC) from the IL-Believe Trial of TransCon IL-2 ?/? + weekly paclitaxel in the second quarter of this year.
- Strategic Collaborations & Investments
- Ongoing multi-product collaboration with Novo Nordisk for TransCon technology-based therapies in obesity and metabolic diseases, with the lead program, TransCon Semaglutide, on track to enter the clinic as anticipated.
- Eyconis lead program, TransCon aVEGF (EYC-0305), in development for wet AMD and other retinal diseases anticipated to enter the clinic in 2026.
- On January 26, 2026, VISEN Pharmaceuticals announced that China’s National Medical Products Administration approved its biologics license application for lonapegsomatropin (TransCon hGH) in China for the treatment of pediatric growth hormone deficiency (PGHD).
- In November 2025, Teijin Limited announced that YORVIPATH is commercially available for prescription in Japan.
- Financial Update
- For the fourth quarter of 2025, operating profit was €10 million and cash flow from operating activities was €73 million, primarily driven by continued growth of YORVIPATH revenue globally.
- Initiating previously announced $120 million share repurchase program in 2026.
- As of December 31, 2025, our cash balance was €616 million, an increase of €77 million compared to €539 million as of September 30, 2025.
Fourth Quarter and Full-Year 2025 Financial Results
Total revenue for the fourth quarter of 2025 was €248 million, compared to €174 million during the same period for 2024. The increase was primarily attributable to the continued growth of YORVIPATH global product revenue, partially offset by the recognition of a $100 million upfront payment in 2024 that did not recur in 2025.
Total revenue for 2025 was €720 million compared to €364 million in 2024. The increase was primarily attributable to the continued growth of YORVIPATH partially offset by recognition of a $100 million upfront payment in 2024 that did not recur in 2025. Non-product revenue was €37 million in 2025, compared to €138 million in 2024.
| Total Revenue (In EUR'000s) | Three Months Ended December 31, | Twelve Months Ended December 31, | ||||||||||
| 2025 | 2024 | 2025 | 2024 | |||||||||
| Revenue | ||||||||||||
| Commercial products | 240,092 | 72,130 | 683,572 | 225,728 | ||||||||
| Services and clinical supply | 4,780 | 5,933 | 18,008 | 15,570 | ||||||||
| Licenses | 2,628 | 95,853 | 5,630 | 122,343 | ||||||||
| Milestones | — | — | 12,922 | — | ||||||||
| Total revenue | 247,500 | 173,916 | 720,132 | 363,641 |
| Commercial Products Revenue (In EUR'000s) | Three Months Ended December 31, | Twelve Months Ended December 31, | ||||||||||
| 2025 | 2024 | 2025 | 2024 | |||||||||
| Revenue from commercial products | ||||||||||||
| YORVIPATH® | 186,677 | 13,584 | 477,412 | 28,727 | ||||||||
| SKYTROFA® | 53,415 | 58,546 | 206,160 | 197,001 | ||||||||
| Total revenue from commercial products | 240,092 | 72,130 | 683,572 | 225,728 | ||||||||
Research and development (R&D) expenses for the fourth quarter of 2025 were €78 million, compared to €79 million during the same period in 2024. R&D expenses for 2025 were €304 million compared to €307 million in 2024. The lower R&D expenses were driven by the completion of clinical trials and development activities within our Endocrinology Rare Disease pipeline partially offset by reversal (income) of prior period write-downs related to YORVIPATH pre-launch inventory.
Selling, general, and administrative (SG&A) expenses for the fourth quarter of 2025 were €136 million, compared to €80 million during the same period in 2024. SG&A expenses for 2025 were €458 million compared to €291 million in 2024. Higher SG&A expenses were primarily due to the continued impact from global commercial expansion, including global launch activities for YORVIPATH.
Total operating expenses for the fourth quarter of 2025 were €214 million compared to €160 million during the same period in 2024. Total operating expenses for 2025 were €761 million compared to €598 million in 2024.
Net finance expenses were €38 million in the fourth quarter compared to €33 million in the same period in 2024. Net finance expenses for 2025 were €93 million compared to €74 million in 2024. The full year net finance expense increase was driven primarily by non-cash items.
For the fourth quarter of 2025, Ascendis Pharma reported a net loss of €34 million, or €0.55 per share (basic and diluted) compared to a net loss of €38 million, or €0.64 per share (basic and diluted) for the same period in 2024. For the full year 2025, Ascendis Pharma reported a net loss of €228 million, or €3.76 per share (basic and diluted) compared to a net loss of €378 million, or €6.53 per share (basic and diluted) in 2024.
As of December 31, 2025, Ascendis Pharma had cash and cash equivalents totaling €616 million compared to €560 million as of December 31, 2024. As of December 31, 2025, Ascendis Pharma had 61,977,408 ordinary shares outstanding, including 597,096 ordinary shares represented by ADSs held by the company.
Conference Call and Webcast Information
Ascendis Pharma will host a conference call and webcast today at 4:30 pm Eastern Time (ET) to discuss its fourth quarter and full year 2025 financial results.
Those who would like to participate may access the live webcast here, or register in advance for the teleconference here. The link to the live webcast will also be available on the Investors & News section of the Ascendis Pharma website at https://investors.ascendispharma.com. A replay of the webcast will be available on this section of the Ascendis Pharma website shortly after conclusion of the event for 30 days.
About Ascendis Pharma A/S
Ascendis Pharma is applying its innovative TransCon technology platform to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients’ lives. Guided by its core values of Patients, Science, and Passion, Ascendis uses its TransCon technologies to create new and potentially best-in-class therapies. Ascendis is headquartered in Copenhagen, Denmark and has additional facilities in Europe and the United States. Please visit ascendispharma.com to learn more.
Forward-Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis’ future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) Ascendis’ expectation for durable, long-term growth, including its expectation to generate approximately €500 million in operating cash flow in 2026 and to deliver at least €5 billion in global annual product revenue by 2030; (ii) Ascendis’ expectations with respect to the commercial launches of TransCon PTH in additional countries; (iii) the PDUFA goal date for FDA review of TransCon CNP; (iv) the timing of EMA’s decision on potential use of TransCon CNP in pediatric achondroplasia; (v) the timing of enrollment completion of the label expansion trial in infants with achondroplasia, reACHin; (vi) the timing of Week 78 COACH data update; (vii) the planned new trials to support TransCon CNP + TransCon hGH treatment in additional indications; (viii) the timing of median OS data for the oncology program; (ix) the clinical entry of TransCon semaglutide; (x) the clinical entry of TransCon aVEGF program in 2026; (xi) Ascendis’ ability to apply its TransCon technology platform to build a leading, fully integrated biopharma company; and (xii) Ascendis’ use of its TransCon technologies to create new and potentially best-in-class therapies. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including the following: dependence on third party manufacturers, distributors and service providers for Ascendis’ products and product candidates; unforeseen safety or efficacy results in Ascendis’ development programs or on-market products; unforeseen expenses related to commercialization of any approved Ascendis products; unforeseen expenses related to Ascendis’ development programs; unforeseen selling, general and administrative expenses, other research and development expenses and Ascendis’ business generally; delays in the development of its programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; Ascendis’ ability to obtain additional funding, if needed, to support its business activities; and the impact of international economic, political, legal, compliance, social and business factors. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis’ business in general, see Ascendis’ Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission (SEC) on February 12, 2025, and Ascendis’ other future reports filed with, or submitted to, the SEC. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward-looking statements, except as required by law.
Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo, TransCon, SKYTROFA®, and YORVIPATH® are trademarks owned by the Ascendis Pharma group.
© February 2026 Ascendis Pharma A/S.
| Investor Contacts: Chad Fugere Ascendis Pharma ir@ascendispharma.com | Media Contact: Melinda Baker Ascendis Pharma media@ascendispharma.com |
| Patti Bank ICR Healthcare patti.bank@icrhealthcare.com | |
FINANCIAL TABLES FOLLOW
| Ascendis Pharma A/S Consolidated Statements of Profit or (Loss) and Other Comprehensive Income or (Loss) (In EUR'000s, except share and per share data) | Three Months Ended December 31, | Twelve Months Ended December 31, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | |||||||||||||
| Consolidated Statement of Profit or (Loss) | ||||||||||||||||
| Revenue | 247,500 | 173,916 | 720,132 | 363,641 | ||||||||||||
| Cost of sales | (23,598 | ) | (14,023 | ) | (94,915 | ) | (44,258 | ) | ||||||||
| Gross profit | 223,902 | 159,893 | 625,217 | 319,383 | ||||||||||||
| Research and development expenses | (78,151 | ) | (79,294 | ) | (303,621 | ) | (307,004 | ) | ||||||||
| Selling, general, and administrative expenses | (135,855 | ) | (80,216 | ) | (457,867 | ) | (291,142 | ) | ||||||||
| Operating profit/(loss) | 9,896 | 383 | (136,271 | ) | (278,763 | ) | ||||||||||
| Share of profit/(loss) of associates | 1,328 | (4,575 | ) | 16,308 | (20,060 | ) | ||||||||||
| Finance income | 24,061 | 26,233 | 113,999 | 25,609 | ||||||||||||
| Finance expenses | (61,990 | ) | (59,425 | ) | (206,687 | ) | (100,027 | ) | ||||||||
| Profit/(loss) before tax | (26,705 | ) | (37,384 | ) | (212,651 | ) | (373,241 | ) | ||||||||
| Income taxes (expenses) | (6,857 | ) | (1,085 | ) | (15,383 | ) | (4,843 | ) | ||||||||
| Net profit/(loss) for the year | (33,562 | ) | (38,469 | ) | (228,034 | ) | (378,084 | ) | ||||||||
| Attributable to owners of the Company | (33,562 | ) | (38,469 | ) | (228,034 | ) | (378,084 | ) | ||||||||
| Basic earnings/(loss) per share | € | (0.55 | ) | € | (0.64 | ) | € | (3.76 | ) | € | (6.53 | ) | ||||
| Diluted earnings/(loss) per share | € | (0.55 | ) | € | (0.64 | ) | € | (3.76 | ) | € | (6.53 | ) | ||||
| Consolidated Statement of Comprehensive Income or (Loss) | ||||||||||||||||
| Net profit/(loss) for the year | (33,562 | ) | (38,469 | ) | (228,034 | ) | (378,084 | ) | ||||||||
| Other comprehensive income/(loss) | ||||||||||||||||
| Items that may be reclassified subsequently to profit or (loss): | ||||||||||||||||
| Exchange differences on translating foreign operations | (490 | ) | 830 | (3,538 | ) | 1,062 | ||||||||||
| Other comprehensive income/(loss) for the year, net of tax | (490 | ) | 830 | (3,538 | ) | 1,062 | ||||||||||
| Total comprehensive income/(loss) for the year, net of tax | (34,052 | ) | (37,639 | ) | (231,572 | ) | (377,022 | ) | ||||||||
| Attributable to owners of the Company | (34,052 | ) | (37,639 | ) | (231,572 | ) | (377,022 | ) |
| Ascendis Pharma A/S Consolidated Statements of Financial Position (In EUR'000s) | December 31, 2025 | December 31, 2024 | |||||
| Assets | |||||||
| Non-current assets | |||||||
| Intangible assets | 3,710 | 4,028 | |||||
| Property, plant and equipment | 146,479 | 98,714 | |||||
| Investments in associates | 32,526 | 13,575 | |||||
| Other receivables | 10,870 | 2,317 | |||||
| 193,585 | 118,634 | ||||||
| Current assets | |||||||
| Inventories | 301,533 | 295,609 | |||||
| Trade receivables | 141,333 | 166,280 | |||||
| Income tax receivables | 1,781 | 1,775 | |||||
| Other receivables | 14,582 | 9,385 | |||||
| Prepayments | 33,715 | 28,269 | |||||
| Cash and cash equivalents | 616,041 | 559,543 | |||||
| 1,108,985 | 1,060,861 | ||||||
| Total assets | 1,302,570 | 1,179,495 | |||||
| Equity and liabilities | |||||||
| Equity | |||||||
| Share capital | 8,322 | 8,149 | |||||
| Distributable equity | (171,143 | ) | (113,855 | ) | |||
| Total equity | (162,821 | ) | (105,706 | ) | |||
| Non-current liabilities | |||||||
| Borrowings | 385,254 | 365,080 | |||||
| Contract liabilities | 1,123 | 5,000 | |||||
| Deferred tax liabilities | 9,623 | 7,258 | |||||
| 396,000 | 377,338 | ||||||
| Current liabilities | |||||||
| Convertible notes, matures in April 2028 | |||||||
| Borrowings | 429,391 | 458,207 | |||||
| Derivative liabilities | 256,231 | 150,670 | |||||
| 685,622 | 608,877 | ||||||
| Other current liabilities | |||||||
| Borrowings | 57,141 | 33,329 | |||||
| Contract liabilities | 4,944 | 936 | |||||
| Trade payables and accrued expenses | 90,657 | 96,394 | |||||
| Other liabilities | 58,204 | 67,956 | |||||
| Income tax payables | 6,427 | 1,222 | |||||
| Provisions | 166,396 | 99,149 | |||||
| 383,769 | 298,986 | ||||||
| 1,069,391 | 907,863 | ||||||
| Total liabilities | 1,465,391 | 1,285,201 | |||||
| Total equity and liabilities | 1,302,570 | 1,179,495 |
FAQ**
What factors contributed to Ascendis Pharma A/S ASND achieving €240 million in product revenue for Q4 2025, and how does this performance compare to previous quarters?
How does the operating profit of €10 million for Q4 20align with Ascendis Pharma A/S ASND’s long-term financial goals and expected growth trajectory?
What strategies is Ascendis Pharma A/S ASND employing to reach the projected €5 billion in global annual product revenue by 2030?
Can you provide insights on the expected impact of the upcoming PDUFA action goal date of February 28, 2026, for TransCon CNP on Ascendis Pharma A/S ASND’s overall product revenue and market position?
**MWN-AI FAQ is based on asking OpenAI questions about Ascendis Pharma A/S (NASDAQ: ASND).
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